StraARS 2023

Aminoacyl-tRNA synthetases : sculpting codes and shaping cell physiology

Scientific Program

08:00 Registration

08:30 Welcome coffee & Registration

09:00 Catherine Florentz University of Strasbourg, VP of Strategic Planning and Actions

University Welcome Talk

09:05 CNRS Representative

CNRS Welcome Talk

09:10 Pierre Antony Co-Organizer CNRS UMR 7104 - Inserm U 1258 – IGBMC/University of Strasbourg

Welcome Talk "The raison d’être of StraARS2023"

09:15 Hubert Becker Co-Organizer UMR 7156 GMGM – IPCB/University of Strasbourg

Welcome Talk and Acknowledgements

DAY 1 – May 23rd

Session 1 : Aminoacyl-tRNA Synthetases : code gatekeeper

Session Chair : Ya-Ming Hou

09:20 Dino Moras Plenary lecture CNRS UMR 7104 - Inserm U 1258 – IGBMC/University of Strasbourg

aaRSs and RNA world a tale to be

10:05 Osamu Nureki Tokyo University, Japan

Amino acid transfer from aa-tRNA to lipids modulates immunity

  • 10:30-11:00 Coffee Break

11:00 Rajan Sankaranarayanan CCMB Hyderabad, India

Discriminatory Tales!

11:25 Richard Giegé IBMC/University of Strasbourg

Primordial tRNA identities for aminoacylation and ancillary identities reveal a tRNA code biology

11:50 Juliette Godin IGBMC/University of Strasbourg

The tRNAs journey through cortical development: Where it started, where it goes?

12:15 Gilbert Eriani UPR 9002 – IBMC/University of Strasbourg

A tRNA mimicry strategy to explore ribosome decoding rules

  • 12:40-14:30 Lunch

14:30 Lluis Ribas de Pouplana IRB, Barcelona, Spain

Signal saturation in tRNAs – shutting the gate?

Session 3 : Aminoacyl-tRNA Synthetases and tRNAs design new physiology

Session Chair : Osamu Nureki

14:55 Hiro Suga Tokyo University, Japan

Genetic Code Reprogramming Facilitated by Flexizymes

15:20 Jesse Rinehart Yale University, USA

Large scale synthetic human phosphoproteome to decode novel protein-protein interaction networks

15:45 Dieter Söll Plenary lecture Yale University, USA

Pyrrolysine and Selenocysteine - different designs to manifest the genetic code

  • 16:30-17:00 Coffee Break

Session Chair : Hubert Becker

17:00 Sunghoon Kim Yonsei University & BIOCON, Korea

Multi-tRNA Synthetase Complex for the Control of Cancer Pathways at Systems Level

17:25 Paul Schimmel Plenary lecture Scripps, California, USA

Brave new world of tRNA synthetase regulation of RNA splicing

DAY 2 – May 24th

Session 2 : Aminoacyl-tRNA synthetases shape synthetic genetic codes

Session Chair : Sunghoon Kim

09:00 Ignacio Luque Csic Sevilla, Spain

Aminoacyl-tRNA synthetases and tRNAs in cyanobacteria, a decade of surprises

09:25 Marie Sissler IECB, Bordeaux

Mitochondrial aminoacyl-tRNA synthetases and connections to diseases

09:50 Frédéric Fischer IPCB/University of Strasbourg

Aminoacyl-tRNA-dependent sterol modifications in fungi

10:15 Constantinos Stathopoulos Patras University, Greece

“Unboxing” the diversity of tRNA-mediated aaRS transcription regulation in pathogens

  • 10:40-11:10 Coffee Break

11:10 Magali Frugier UPR 9002 – IBMC/University of Strasbourg

Two aminoacyl-tRNA synthetase complexes, membrane localization and unusual role in tRNA import: many questions remain about tRNA biology in Plasmodium

11:35 Leslie Nangle aTyr Pharma, USA

Developing Novel Therapeutics Based on Aminoacyl-tRNA Synthetases

12:00 Hubert Becker - Co-organizer

Concluding remarks

12:05 Pierre Antony - Co-organizer

Invitation to a musical journey

12:10 Strasbourg University student choir – direction – Amanda Hascher

Georges Bizet – Carmen – Chœur des cigarières

Wolfgang Amadeus Mozart – Cosi fan tutte – Secondate

Jean-Philippe Rameau – Rondeau des Indes galantes

Gaetano Donizetti – La Fille du régiment – Rataplan

Giuseppe Verdi – La Traviata – Chœur des bohémiennes et chœur des matadores

12:35 University of Strasbourg Representative

Conclusion of StraARS2023

  • 12:40-14:30 Lunch

08:30 Welcome coffee

Session 3 : Aminoacyl-tRNA Synthetases and tRNAs design new physiology